Posted February 11, 2008 10:05 AM
 ASU mixed in a ratio of 1:2 has been studied in the treatment of osteoarthritis and other connective tissue disorders. ASU was administered for 45 days in a three month prospective, randomized, double blind placebo controlled trial and decreased the total dose of NSAIDS required. The trial consisted of 164 patients with knee or hip osteoarthritis. NSAIDS include medications such as Advil, Aspirin, Motrin, Ibuprofen, Aleve, Naprosyn, Daypro, Feldene, Piroxicam, and etcetera.
A six month randomized, double blind, placebo controlled trial consisted of 114 patients with knee osteoarthritis and 50 patients with hip osteoarthritis. The patients received 300 mg/per day of ASU or a placebo, followed by a two month post treatment follow up. In comparison to the placebo group, patients who received ASU demonstrated significantly less pain and disability. This persisted throughout the trial as well as four eight months beyond.
Two other combined studies of ASU have demonstrated positive effects on pain, intake of NSAIDS, functional index and global evaluation.
Mild gastrointestinal discomfort may occur with ASU use. Currently, there is insufficient data on drug interactions.
References: Register et al. Evidence of Nutraceutical Effectiveness in the Treatment of Osteoarthritis. Curr Rheumatol Rep, 2000: #2: 472-7.
Mahew et al. Symptomatic Efficacy of Avocado/Soybean on Unsaponifiables in the Treatment of Osteoarthritis of the Knee and Hip.
Arthritis and Rheum, 1998; 41: 81-91. Little, C., Herbal Therapy for Treating Osteoarthritis. Cochrane Data Base. Syst. Rev. 2001. |
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